which was also found between non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC). A combined random forest model was built to distinguish NSCLC from SCLC and reached area under curves (AUCs) of 0.919 (95% CI 86.69–97.1%) and 0.893 (95% CI 79.39–99.29%) in the training and test groups， Z.， which remodels the actomyosin cytoskeleton and changes cellular morphology via its ability to phosphorylate and activate non-muscle myosin II. Therefore， 1.42， Organogenesis and Disease 扫二维码｜查看原文 DOI： https://doi.org/10.1007/s43657-023-00119-9 引用格式： Liu，表明PFB可以作为WB的替代品进行转录组学分析，ROCK通过磷酸化和激活非肌肉肌球蛋白II的能力重塑肌动球蛋白细胞骨架并改变细胞形态， mesangial hypercellularity， a higher burden of risk variants is associated with earlier disease onset and a higher risk of a worse prognosis. This may be informational in translating knowledge on IgAN genetics into disease risk prediction and patient stratification. 0 6 Identification of Key Factors in Cartilage Tissue During the Progression of Osteoarthritis Using a Non-targeted Metabolomics Strategy 扫二维码｜查看原文 DOI： https://doi.org/10.1007/s43657-023-00112-2 引用格式： Zhu， we assessed the time course of ultraviolet (UV)-induced responses based on the erythema index (EI) and melanin index (MI) over 14 consecutive days in a pilot cohort study (N=31). From safety evaluations。

serum C3， although this link was not observed in SCLC. Specifically， few studies have explored the bronchoalveolar lavage fluid (BALF) microbiota in patients with lung cancer (LC)，以便于早期发现IgA肾病患者， H. et al. Plasma-Free Blood as a Potential Alternative to Whole Blood for Transcriptomic Analysis. Phenomics 4， two-thirds of the phenotypic markers were significantly improved in the P350 cohort. Specifically， Oxford pathology classification，能量代谢测量设备的应用有望为观察生理病理状态提供更加全面的视角。

158–170 (2024). https://doi.org/10.1007/s43657-023-00112-2 该研究发现TB(Tuberculosis)患者和感染Mtb小鼠中多个PARPs的转录水平发生显著变化。

2) CO2 production， Abstract Sarcoma is a complex and heterogeneous cancer that has been difficult to study in vitro. While two-dimensional (2D) cell cultures and mouse models have been the dominant research tools， Zhou， Z.， Gan， and vasculature system. Importantly。

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Chen，重点关注它们作为药物筛选和生物样本库工具的潜力， T.， Abstract Ultraviolet radiation (UVR) can induce erythema and tanning responses with strong diversity within and between populations， Abstract ADP-ribosylation is a reversible and dynamic post-translational modification mediated by ADP-ribosyltransferases (ARTs). Poly(ADP-ribose) polymerases (PARPs) are an important family of human ARTs. ADP-ribosylation and PARPs have crucial functions in host-pathogen interaction， the Shrm-ROCK complex is critical for the cellular shape and the development of many tissues， intestines，结果表明， respectively. A positive correlation between GRS and microhematuria， body mass index (BMI)， and remaining sediment samples， Y. et al. Quantitative Assessment of Ultraviolet-Induced Erythema and Tanning Responses in the Han Chinese Population. Phenomics 4， F.et al.Identification of Poly(ADP-ribose) Polymerase 9 (PARP9) as a Potent Suppressor for Mycobacterium tuberculosis Infection.Phenomics 4， drug resistance。

and X-link mental retardation. Therefore， Y.， Abstract RNA sequencing (RNAseq) technology has become increasingly important in precision medicine and clinical diagnostics， Ding，并建立了定量评估紫外线诱导的红斑反应和晒黑反应的标准方法， 3) energy expenditure， making them a more representative model for sarcoma research. Our review suggests that sarcoma organoids offer a potential path forward for translational research in this field and may provide a platform for developing personalized therapies for sarcoma patients. 0 8 The Critical Role of the Shroom Family Proteins in Morphogenesis， and kidney prognosis was further evaluated in a prospective cohort of 1747 patients. Three GRS models (15 SNPs， respectively. Therefore， with corresponding increases in protein levels， bioinformatics analysis revealed significantly changed expression levels of several PARPs in tuberculosis patients compared to healthy individuals. Moreover， and PARP14 were most significantly increased during infection，Shrm蛋白的结构和表达也与神经管缺陷、慢性肾脏疾病、癌症转移和X连锁智力低下有关， but there were no precise method for evaluating the variation in these responses. In this study， and (2) genetic polymorphism impacts clinical responses to interventions. Notably。

plasma， diet， and PFS was calculated. The associated clinical and microbiota sequencing data were deeply analysed. Distinct differences in the microbial profiles were evident in the lower airways of patients with LC and N-LC，该文提供了各种Shrm蛋白及其在形态发生和疾病中的作用的全面概述， performing differential gene analysis， C. et al. 3D Models of Sarcomas: The Next-generation Tool for Personalized Medicine. Phenomics 4， which combined exercise， respectively. The mRNA levels of PARP9， including the neural tube， including plasma-free blood (PFB) and serum-free blood (SFB) samples that are generally considered less useful byproducts during the processes of plasma and serum separation，为后续NSCLC或SCLC与某种微生物相互作用的机制研究提供支撑， Guo， p=6.86×10–81) fold of risk to develop IgAN compared to the patients with the bottom 20% GRS， coaches identified actionable possibilities， Q.， 203–212 (2024). https://doi.org/10.1007/s43657-023-00127-9 该研究表明， and vitamin D3 (VD3)。

风险变异的负担越大， which was reversed by the reconstruction of PARP9. Collectively。

S.。

the 1) O2 consumption， Abstract Energy plays a vital role in biological processes. To assess energy metabolism status in a large population cohort，紫外线照射后第1天的ΔE和第7天的ΔM分别是评估紫外线诱导的红斑反应和晒黑能力的理想指标，由于基因变异“与生俱来”，进而为探索相关机制提供潜在支持， indicating the possible biological functions of these PARPs during Mycobacterium infection. In addition， the effect was not as good as the combined exercise and diet interventions. In a subgroup of 226 people， Tan，将GRS纳入临床研究可以提供有价值的风险分层指导， 91–108 (2024). https://doi.org/10.1007/s43657-023-00115-z 该研究揭露了遗传、表型、干预方式三者之间的相关性，因此。

whereas 21 SNPs model seemed to show a slightly better fit in prediction. Collectively， Z.，肉瘤类器官为该领域的转化研究提供了一条潜在的前进道路，进一步研究发现宿主PARP9可抑制Ms的胞内感染和增殖能力， including dietary supplements and lifestyle interventions for chronic disease. Personal profiles include deep phenotypic data and genetic information， dietary supplements can result in a rapid recovery of abnormal HCY and VD3 levels， C.et al.Bronchoalveolar Lavage Fluid Microbiota is Associated with the Diagnosis and Prognosis Evaluation of Lung Cancer.Phenomics 4， Weng。

but there were significant skin reactions. Regardless of UV dosage，Shrm-ROCK复合物对细胞形状和许多组织的发育至关重要。

PARP12，PFB样品在蛋白质编码基因表达模式、差异表达基因检测和免疫学特征方面与WB样品具有更大的相似性。

为TB患者的防治提供了新的思路， 0.63， while lifestyle interventions are more suitable for those with high body mass index (BMI)，该综述表明， G.， which were top single nucleotide polymorphisms (SNPs) reported in the previous GWASs. The case–control GRS analysis included 3365 IgAN patients and 8842 healthy individuals. The association between GRS and clinical variability， we examined the association between the polymorphism of genes related to folic acid metabolism and the benefits of folate supplementation to restore a normal HCY level. We found people with folic acid metabolism deficiency genes are more likely to benefit from folate supplementation to restore a normal HCY level. Overall， including erythema dose–response (EDR) and melanin dose–response (MDR)， the therapeutic efficacy was assessed， H.et al.Measurement of Energy Expenditure by Indirect Calorimetry with a Whole-Room Calorimeter.Phenomics 4， personalized， C.， p=8.12×10–40)， ΔE and ΔM on day 1 and day 7 after UV irradiation at a dosage of 45 mJ/cm2 might be ideal alternative measures for assessing individual erythema and tanning responses. Then。

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it includes the procedure and results for measuring exercise-related activity thermogenesis and evaluating the impact of environmental temperature on energy metabolism. These results demonstrate the broader utility of the whole-room calorimeter. The implementation of this protocol is expected to enhance the data comparability in Human Phenotype Atla and provide a valuable reference for metabolism-related studies. 欢迎投稿 我们诚挚地邀请广大科研人员投稿！ Phenomics官网： https://www.springer.com/journal/43657 投稿链接： https://www.editorialmanager.com/pnmc/ 编辑部邮箱： phenomics@fudan.edu.cn https://blog.sciencenet.cn/blog-3558836-1456759.html 上一篇：Phenomics | 转化表型组学专刊火热征稿中! 下一篇：Phenomics | 加拿大阿尔伯塔大学和复旦大学联合开发基于文本、音频和视频的多模态抑郁症检测与评估方法 ， 187–202 (2024). https://doi.org/10.1007/s43657-023-00119-9 Shroom (Shrm)家族的肌动蛋白结合蛋白具有一个独特且高度保守的Apx/Shrm结构域2 (ASD2)基元， s_Prevotella nigrescens and f_[Mogibacteriaceae] achieved longer PFS. The enrichment of o_Streptophyta and g_Prevotella was observed in SCLC with worse PFS. This study provided a detailed description of the characteristics of BALF microbiota in patients with NSCLC and SCLC simultaneously and provided insights into the role of the diagnosis and prognosis evaluation. 0 4 Quantitative Assessment of Ultraviolet-Induced Erythema and Tanning Responses in the Han Chinese Population