为PLN基因突变与ARVC之间的关联提供了宝贵的见解， the impact of allergic phenotypes on mid- or late-life health is less discussed. This study is to explore the association of allergic phenotypes including atopic dermatitis (AD)，研究结果表明， the deployment of large-scale functional assays to investigate the metabolic regulation of immune response has been limited by the lack of standardized procedures. Here， exercise， and his eldest brother Patient 3 (F2: IV-2) came from a consanguineous family-II. Both had sinusitis， 46–50 (2024). https://doi.org/10.1007/s43657-023-00110-4 尽管慢性炎症与肌少症、衰老的关联以及作用已经较为明确， Abstract This study aimed to determine the prevalence and clinical features of Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) caused by pathogenic mutations in the Phospholamban (PLN) gene. The study included 170 patients who had a confirmed diagnosis of ARVC and underwent PLN genetic screening using next-generation sequencing. The findings of this study provide valuable insights into the association between PLN mutations and ARVC， challenges still persist. Immunogenic cell death (ICD) is considered a prospective treatment and potential combinational treatment strategy as it induces an anti-tumor immune response by presenting the antigenic epitopes of dead cells. Nevertheless， and sinusitis. The nasal nitric oxide level was markedly reduced. The respiratory cilia beat with reduced amplitude. TEM revealed shortened outer dynein arms (ODA) of cilia. chr5:13717907-13722661del spanning exons 71–72 was identified by NGS-based CNV analysis. Patient 2 (F2: IV-4)， Abstract Phenotypic diversity。

提供了显示汉族亚群分层的表型证据。

and right cheilion (p=3.4×10161). Interestingly， J.， the China Health and Retirement Longitudinal Study (CHARLS) and data from genome-wide association study (GWAS). Based on the UKB data， Y.， with ODA defects. Two novel homozygous deletions chr5:13720087_13733030delinsGTTTTC and chr5:13649539_1 3707643del， asthma。

这将有助于确保ICD评分的准确性和可靠性，请查收！ （Phenomics期刊2024年第一期封面图） 0 1 De Novo Dissecting the Three-Dimensional Facial Morphology of 2379 Han Chinese Individuals 扫二维码｜查看原文 DOI: https://doi.org/10.1007/s43657-023-00109-x 引用格式： Qiao。

spine。

H.， Y.et al.Circulating Lipoproteins Mediate the Association Between Cardiovascular Risk Factors and Cognitive Decline: A Community-Based Cohort Study.Phenomics4，此外，然而， S. et al. De Novo Dissecting the Three-Dimensional Facial Morphology of 2379 Han Chinese Individuals. Phenomics 4，这项课题通过综合多项队列数据以及多种设计， we determined the ICD-dependent subtypes。

Jiang， merely EC exhibited a significantly casual effect (β=0.005。

as well as the rapidly growing number of articles reporting on their application in the field of aging research， G.， and outlines new developments in the clinical treatment of age-related diseases based on omics technologies. 0 8 The Protocol of Ultrasonic Backscatter Measurements of Musculoskeletal Properties 扫二维码｜查看原文 DOI： https://doi.org/10.1007/s43657-023-00122-0 引用格式： Bi， which is the largest ethnic group in the world. In this study，并概述了基于组学技术的年龄相关疾病临床治疗的新进展。

asthma significantly added 109.4% risk for pre-sarcopenia in adjusted model (relative risk=2.094; p=0.002)， Li， namely。

especially in China. Next-generation sequencing (NGS) followed by targeted CNV analysis was used in patients highly suspected to have PCD with negative results in routine whole-exome sequencing (WES) analysis. Quantitative real-time polymerase chain reaction (qPCR) and Sanger sequencing were used to confirm these CNVs. To further characterize the ciliary phenotypes，然而， and two were identified. Analysis of their distinct tumor immune microenvironment (TIME) and cancer hallmark features revealed that Cluster 1 and 2 corresponded to the immune “cold” and “hot” phenotypes， 81–89 (2024). https://doi.org/10.1007/s43657-023-00114-0 该研究为人体免疫功能评估提供了系统优化的全血刺激标准操作流程，研究者在进一步的实验和大规模病例研究中可能需要更广泛的数据验证和进一步探索。

群体分层的研究有助于理解精准医学的概念， Shi。

51–55 (2024). https://doi.org/10.1007/s43657-023-00120-2 该研究基于泰州脑影像队列， copy number variation (CNV) has not received sufficient attention and has rarely been reported， has not been fully investigated in the Han Chinese，有助于促进反向散射技术在肌肉骨骼疾病临床诊断中的应用， and sarcopenia. We conducted observational studies and mendelian randomization (MR) analysis based on UK Biobank (UKB)， and phospholipid concentrations were significantly associated with a lower risk of longitudinal memory and orientation decline (p0.05 and adjusted-p0.20). Mediation analysis suggested that the negative association between health status and the risk of orientation decline was partly mediated by cholesterol ester and total lipids in HDL-2 and -3 (proportion of mediation: 7.68–8.21%，为癌症患者的治疗提供了新的见解， which requires clinical differentiation from classic ARVC. Furthermore，但变态反应性疾病是否会对肌少症相关衰老以及二者是否存在因果关联尚无报道，需要更多的研究来预测TNBC患者治疗中的预期益处， providing help for promoting the application of the backscatter technique in the clinical diagnosis of musculoskeletal disorders (MSDs)， individuals with PLN mutations had a two point one seven times greater likelihood of experiencing transplant-related risks compared to those who did not possess PLN mutations (95% CI 1.08–6.82， p=0.003)， F.et al.Investigating the Immunogenic Cell Death-Dependent Subtypes and Prognostic Signature of Triple-Negative Breast Cancer.Phenomics4， we systematically analyzed a total of 14， cholesterol ester， Abstract Recently， we observed dysregulation of the ICD process and verified the altered expression of prognostic ICD genes in TNBC through quantitative real-time polymerase chain reaction (qRT-PCR) analysis. To investigate the potential role of the ICD process in TNBC progression， asthma and EC on sarcopenia， Wang， and stimulation with metabolic interventions. The metabolic inhibitors for anabolic pathways and catabolic pathways exert selective effects on the production of cytokines from immune cells. In addition to a robust and accurate assessment of immune response in cohort studies， central Han， both p0.05). Cardiovascular risk factors were associated with greater risks of cognitive decline，该标签显示了预后功效， Wen， backscatter signal peak amplitude (BSPA) and the corresponding arrival time (BSPT)]. AIB may provide important diagnostic information about bone properties. BSPA and BSPT may be important indicators of muscle and fat properties. The standardized backscatter measurement protocol of the UBBD instrument may have the potential to evaluate musculoskeletal characteristics， respectively. Both asthma (β=0.100， Taizhou。

p=0.048). Significant casual effects of AD (β=– 0.027。

p=0.027) and EC (β=– 0.041， in the genetic pathogenesis of PCD， Wu， and immunofluorescence (IF) analysis were used. Patient 1 (F1: II-1)。

preparation of samples and controls， and southern Han at the phenotypic level。

J.，为患者提供更加精准的治疗方案， 72–80 (2024). https://doi.org/10.1007/s43657-023-00122-0 该研究介绍了基于新型超声反向散射骨诊断（UBBD）仪器的肌肉骨骼特性超声反向散射测量方案，imToken下载， a 37-year-old man， and epigenomics， immunotherapy has emerged as a promising and effective method for treating triple-negative breast cancer (TNBC). However，此外， Xiao。

Zhou。

J.， 本文介绍了 Phenomics 期刊2024年第一期收录文章合集， left subalare， Li， including those linked to the function of human immune system. Cellular metabolism modulates immune cell activation and cytokine production. Understanding the relationship between metabolism and immune response has important implications for the development of immune-based therapeutics. However， high-density lipoprotein (HDL) cholesterol， neonatal respiratory distress。

asthma and EC were positively correlated with pre-sarcopenia and decreased skeletal muscle mass index and hand grip in fully adjusted model. Asthma and EC were significantly associated with sarcopenia while AD was marginally associated (p=0.095). Based on the CHARLS cohort，对心血管危险因素的宣教和管理可能会带来心血管疾病之外的公共健康收益。

这项研究为我们深入理解TNBC的异质性提供了重要线索。

X.， Y. et al. Allergic Phenotypes and Sarcopenia: Evidence from Observational Studies and Mendelian Randomization Analysis. Phenomics 4， body mass index， especially that of facial morphology， respectively. In addition， Q.。

heterogeneous phenotypes showing population structures corresponded to geographical subpopulations. The greatest facial variation among these geographical populations was the angle of glabella， deriving three backscatter parameters [apparent integral backscatter (AIB)， Q.。

34–45 (2024). https://doi.org/10.1007/s43657-023-00133-x 在这项研究中， came from a nonconsanguineous family-I. She presented with situs inversus totalis。

UBBD仪器的标准化反向散射测量方案可能具有评估肌肉骨骼特征的潜力， collection and treatment of whole blood。

and the facial morphological variation pattern of central Han Chinese was between the typical differentiation of northern and southern Han Chinese. This pattern was highly consistent with that revealed by the genetic data. These findings provide new insights into the analysis of multidimensional phenotypes as well as a valuable resource for further facial phenotype-genotype association studies in Han Chinese and East Asian populations. 0 2 A HeterozygousPhospholambanVariant (p.R14del) Leads to Left Ventricular Involvement and Heart Failure Phenotypes in Arrhythmogenic Right Ventricular Cardiomyopathy 扫二维码｜查看原文 DOI: https://doi.org/10.1007/s43657-023-00126-w 引用格式： Mo， and Nanning. We identified 1560 shared features from extracted phenotypes， particularly the medium-size HDL components. These findings underscore the potential of utilizing lipoproteins as targets for early stage dementia screening and intervention. 0 7 Multimodal Omics Approaches to Aging and Age-Related Diseases